The UnVaccinated are in for a big surprise.....

Bivalent vaccines contain two different components. One component is to protect us against the original viral strain, while the other targets the most recent variants.

(I cut out main point snippets cuz this is one long assed article.)

Vaccine strategy targeting the SARS-CoV-2 virus is challenged in the COVID-19 battle. (Shutterstock/Lightspring)

By Yuhong Dong 11/6/2023
Updated: 11/8/2023

SARS-CoV-2 Variants

From 2020 to early 2021, a number of major SARS-CoV-2 variants have appeared:

• Alpha (B.1.1.7),
  
  
• Beta (B.1.351),
  
  
• Gamma(P.1), and
  
  
• Delta (B.1.617.2).
  
  Not including those old variants:
  
  
  
• Omicron (B.1.1.529) was first reported in South Africa in November 2021, it quickly evolved into a few sister lineages:
  
  
• BA.1,
  
  
• BA.2,
  
  
• BA.4,
  
  
• BA.5,
  
  
• XBB.1.5,
  
  
• EG.5, and
  
  
• HV.1,
  
  A key mutation in spike protein called N501Y, which can escape from vaccine protection, was discovered in alpha. It was also found in two other major variants prevalent during that time and significantly increased in the rate at which it spread.
  
  Shortly thereafter, Delta (B.1.617.2) emerged and presented even more enhanced transmissibility and vaccine escape ability with its intriguing spike protein double mutations of L452R and E484Q, refreshing the viral spreading and escaping records. It was designated as a “variant of concern” by the World Health Organization (WHO) on May 11, 2021.
  
  These double mutations in the spike protein cause the vaccine-induced antibodies to significantly lose their ability to bind to delta, resulting in immunological evasion and causing major global havoc.
  
  The increased binding affinity caused by delta makes it much easier to replicate in human cells. It was reported that patients infected with delta had a viral load 1000 times greater than patients with the original strain. It’s also been able to spread twice as fast as the original SARS-CoV-2 virus.
  
  In July 2021, preliminary data from Israel showed that Pfizer’s vaccine efficacy was significantly reduced at five and six months after vaccination to 44 percent and 16 percent, respectively.
  
  In a July 2021 outbreak in Massachusetts, 74 percent of breakthrough infections occurred in fully vaccinated persons, and the delta variant was detected in 90 percent of them.
  
  The first round of the battle between the vaccine and the virus concluded with an overwhelming vaccine failure when the first generation of the COVID-19 mRNA vaccine met the unexpected delta variant.
  
  Vaccine Versus Virus: The First Battle Round
  Vaccine: Monovalent.
  Result: The vaccine failed.
  
  Since then, a concern regarding the vaccine strategy of generating vaccine escape variants has been raised by scientists, including researchers from Michigan State University.
  
  Second Generation Vaccine: XBB.1.5 Won
  
  People continued to witness the declining effects of the original vaccine against delta, even after boosters were widely administered. The government continually stressed that the original vaccines had sufficient efficacy, one time after another.
  
  Almost all of Omicron and its subvariants have developed specific mutations that have made them spread more quickly while evading our immune response. It has been clearly defined as an immune escape strain according to this Nature review.
  
  A surprising virus, Omicron (B.1.1.529) surged more quickly than any previous strain and completely took over by April 2022. This emergence of hypermutated, increasingly transmissible Omicron variant significantly threatened the vaccine strategy.
  
  It harbors multiple amino acid mutations in the spike (including Q498R and N501Y), which significantly enhance binding to the ACE2 receptor. It has also altered the cell entry pathway which further contributes to its ability to escape from vaccine protection.
  
  On August 31, 2022, the FDA approved the bivalent booster shots of COVID-19 mRNA vaccines designed to target the Omicron subvariants BA.4 and BA.5, with Pfizer only providing the data on eight mice.
  
  Not surprisingly, the antibody levels to XBB.1.5 in bivalent mRNA-boosted individuals declined significantly to pre-booster levels after only three months. The bivalent booster vaccine effectiveness against COVID-19-associated hospitalization declined to as low as 24 percent at six months post-vaccination, according to CDC data collected from September 2022 to April 2023.
  
  The second round ended when the second generation bivalent mRNA vaccine encountered the XBB.1.5 starting in April 2023.
  
  Vaccine Versus Virus: The Second Battle Round
  Vaccine: Bivalent mRNA.
  Result: The vaccine failed.
  
  As of September 2023, the Pfizer-BioNTech and Moderna mRNA vaccines have been reformulated—for the third time.
  
  However, one month before the 3.0 vaccine was approved, the dominant virus had already changed from XBB.1.5 to EG.5—the “Eris” variant, which spreads faster and has a stronger ability to escape from the XBB.1.5 vaccine.
  
  Vaccine Versus Virus: The Third Battle Round
  Vaccine: XBB.1.5 mRNA.
  Result: Vaccine doomed to fail.
  
  Time lapsed: Less than one month from the XBB.1.5

booster vaccine launch in October 2023 to the U.S. dominant wave of vaccine escape by EG.5 or other cousin variants in October 2023.

Omicron continues to change from

• XBB to
  
  
• JN,
  
  
• HK.3,
  
  
• EG.5, and
  
  
• HV.1 —all belonging to the huge and diversified Omicron family.
  
  
• EG.5, carrying an additional F456L mutation, is significantly more resistant to neutralization by the sera from vaccinated people.
  
  That means even the most recent version of the COVID-19 vaccine based on XBB.1.5 is going to lose its protection with EG.5. Since the risk of breakthrough infection remains high, the WHO listed EG.5 as a “varia nt of concern” in early August.
  
  While HV.1 shares almost all spike mutations that EG.5 carries, it took on a surprising additional mutation (L452R) from a remote ancestor delta variant in 2011, which had normally disappeared in the omicron variant. HV.1 can further escape the XBB.1.5-based vaccine-induced immunity and is even more evasive than EG.5.
  
  The same detour trick of HV.1 is also used by JN.1 coming on the scene in August 2023. It gains an additional L455S mutation, switching from the XBB sublineage to BA.2.86 (Pirola).
  
  The HK.3 virus has played a novel trick. It has two mutations in the adjacent spike 455 and 456 positions (L455F and F456L), thus called a “FLip.” Together, this virus binds even more tightly to ACE2 and is taking off slowly in Brazil and Spain.
  
  Both HK.3 (FLip) and JN.1 present even lower binding affinities, meaning the vaccine is even less effective than the current version, raising further concerns over vaccine strategy.
  
  All these new variants are a direct result of the so-called vaccine-escaped viral mutations.
  
  This is a tiring battle between vaccines and the virus. The winners and losers are clear.
  
  Alerts have been raised and major concerns have been discussed by scientists as early as 2021 in top-ranked journals including The Lancet and Nature in addition to Nature Reviews, eBioMedicine (part of The Lancet Discovery Science), and other publications through 2023.
  
  The common view is that the pressure exerted on viruses from repeated vaccination programs serves as a primary driver of the diversified variants of SARS-CoV-2.
  
  If humans continue to develop vaccines based on these emerging new variants, there will continue to be repeated failures. How many more failures will it take to realize that all of these vaccine efforts have been in vain?
  
  It is a time for rational deliberation to pause to reflect on finding the root cause of the viral infection.
  
  We already have a dynamic shield of protection against serious viral attacks—our natural immunity. Only by facing our own innate immunity will the virus find its tricks useless.
  
  Yuhong Dong Author (M.D., Ph.D.)
  
  Dr. Yuhong Dong is a former senior medical scientific expert and pharmacovigilance leader at the Novartis headquarters in Switzerland and a four-time Novartis award winner. She has preclinical research experience in virology, immunology, oncology, neurology, and ophthalmology, and also has clinical experience in infectious disease and internal medicine. She earned her MD and a doctorate in infectious diseases at Beijing University in China.
  
  
  
  The Moral? All they are doing is chasing their tails if it ever really worked in the first place and they are now pushing what amounts to placebos, the lastest in the scientific world is that the vaxs are causing the variants.

 

Glad I didn't need to know that.

 

Depends how you define "know". If you mean you didn't need to know what one particular doctor concluded, then you probably should see what the experts say:

Myths and Facts about COVID-19 Vaccines | CDC
"COVID-19 vaccines do not cause new variants.
FACT: New variants of the COVID-19 virus happen because the virus that causes COVID-19 constantly changes through a natural ongoing process of mutation (change). COVID-19 vaccines do not create or cause variants of the virus that causes COVID-19. As the COVID-19 virus spreads, it has more opportunities to change."

Delta: Have COVID vaccines caused mutations? – DW – 07/12/2021
"How do mutations arise?
Viruses smuggle their genetic information into a host cell in order to multiply. With every reproduction, there are small copying errors, and each of these errors also changes the genetic code of the virus. So it is constantly mutating, and that is quite normal.

Sometimes these mutations make the virus more effective, for example, by allowing it to elude immune reactions such as those brought about by vaccinations or prior illness. Sometimes they make the virus less effective, that is, weaken it. And often they have no effect at all.

In the evolution of virus mutations, the following applies: The strongest variant prevails. In the case of the coronavirus, this means that variants that are more infectious, for example, suppress the less dangerous forms of the virus."

 

I wrote that basically to say I didn't read it because it was too ponderous for me to take the time. I don't have time to read yours either.

 

Summary: He's talking crap, my references prove it.

 

Good for you.

 

Reality: The vaccine worked quite well against the original strain of covid. It worked less well against delta, which unfortunately was also more virulent, but still had some efficacy regardless, particularly for reducing disease severity. Then, eventually, omicron prevailed, and most people moved on from even thinking about covid because the pandemic ended and this less virulent version of covid will be with us indefinitely.

 

The science says thats not true

 

Science, huh? So you have a source for this graphic?

 

They can inject their garbage into my cold dead white ass because that's the only way they're ever vaccinating this person sitting here

 

No, he doesn't. It was spammed on two other threads where I was given the run-around!

Here's one from a reputable source, same time frame, same country:
COVID-19 deaths by vaccination status in England 2022 | Statista


It's quite bad just looking at it, but it's way worse than it appears because that section of unvaccinated makes up around 10% of the UK population!
Covid vaccine: How many people are vaccinated in the UK? - BBC News

The unvaccinated ARE in for a big surprise!

 

I guess as Trump handled the vax, so they do not trust it

 

Sure goog Josh Sterling or Ron Johnsons Senate hearing on covid.

 

Ok, I did a "goog" on that phrase:
UK data misrepresented in false COVID-19 vaccine claim | AP News
Fact-checking Sen. Ron Johnson’s anti-vaccine misinformation | CNN Politics
Analysis by insurance executive Josh Stirling misrepresents official UK data, doesn’t show that COVID-19 vaccines led to 600,000 deaths - Health Feedback

These are US politicians, why, all of a sudden do conspiracy theorists trust them? The hilarious answer is that now they are offering crap that supports their lies!

 

Please stop spamming thread with this misleading nonsense.

 

Hilarious! The OP suggests an action to be taken and calls the results "spamming".

 

You posted misleading garbage and spammed across several threads.
The above is just someone elses opinion.
Nothing to see here folks.
Well unless you like misleading garbage, and someone elses opinion.

 

The variants are the result of evolution which is permitted to occur because, stupid.

 

the variants have grown exponentially as we can see and that is fed by the vaxs that are not a vax at all.

 

When you give a bug a place to live
The bug does what bugs do
It multiplies and changes.
But if you take away the bug's happy home
its numbers decrease and that version goes extinct.

You are the cause of your own problem
AND
Thanks to your overwhelming desire to "own the libs" by getting sick...
A moronic idea
You helped Biden defeat Trump in 2020
You helped the DEMS beat the GOP in 2022

Thanks for your help from President Biden

 

A lie, no I didn't.

Nope, it's actual evidence that your claim is batshit.

As can be said about any one of the dozen spam threads you've created.

As can REALLY be said about any one of the dozen spam threads you've created.

Total hogwash.

Yes they are.

https://scienceexchange.caltech.edu...navirus-sars-cov-2/variants-vaccines-covid-19
"Viruses reproduce by taking over the replication machinery of host cells to make copies of their own genetic material, or genome. Unlike cellular organisms, whose genomes are made of DNA, viruses can encode their genomes as either DNA or RNA. Coronaviruses like SARS-CoV-2—the virus responsible for COVID-19—use RNA to store their genetic information, and copying RNA is more prone to mistakes than copying DNA. Researchers have shown that when a coronavirus replicates, around 3 percent of its copies contain a new random error, also known as a mutation."

 

More disinformation, the vax binds foreign DNA to chromosome 10 and 12 in the human genome, it is a DNA treatment.

The chart you posted is disinfo.

 

Hmmm, Statista using data from official sources is disinfo now, as we are treated to total batshit claims.

Yep, indeed. That IS misinformation. The other word BS is more appropriate though.

 

Just because you post a graph and source it doesnt mean its valid. I dont think you even know what that graph is about.

Its been tested and peer reviewed, duh

 

Hilarious irony. This from somebody who dumped one up without any link that is completely fabricated.

Way more than you.

Hmm, raw data doesn't need either, duh.