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COVID-19 Research, Drug trials and Pathophysiology

Discussion in 'Coronavirus (COVID-19) News' started by Bowerbird, Apr 13, 2020.

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  1. WillReadmore

    WillReadmore Well-Known Member

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    Not a validated peerr test - BUT:

    The famous case of the sailors on the aircraft carrier has a significant update.

    Those infected were treated and kept quarentined until they took multiple tests that showe they had become negative.

    Now, 13 of those sailors test POSITIVE again.

    So, what does this mean about "immunity"?

    https://www.politico.com/news/2020/...velt-sailors-test-positive-coronavirus-261873

    There are medical experts who think this may be because those who have been positive may have viral debris that has not gone away and may manage show up in a subsequent test - even though someone has tested negative several times.

    But, they also say that our understanding of COVID immunity is limited and that there are already changes in Coronavirus significant enough to track where different strains came from most recently.

    Comments anyone?
     
    Last edited: May 19, 2020
    WillReadmore, May 19, 2020
    #226
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  2. Bowerbird

    Bowerbird Well-Known Member

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    Excellent warning in relation to how HCQ may in fact make COVID worse
     
    Bowerbird, May 19, 2020
    #227
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  3. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, May 19, 2020
    #228
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  4. Bowerbird

    Bowerbird Well-Known Member

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    More on the effects of QTC prolongation

     
    Bowerbird, May 19, 2020
    #229
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  5. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, May 19, 2020
    #230
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  6. Sallyally

    Sallyally Well-Known Member Donor

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    Something to do with the testing equip’t perhaps?
     
    Sallyally, May 20, 2020
    #231
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  7. Bowerbird

    Bowerbird Well-Known Member

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    What they think is happening is it is picking up remnant RNA strands
     
    Bowerbird, May 20, 2020
    #232
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  8. BaghdadBob

    BaghdadBob Well-Known Member

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    CATASTROPHE: 20% Of Human Test Subjects Severely Injured From Gates-Fauci Coronavirus Vaccine By Moderna
    By Robert F. Kennedy Jr.

    https://www.fort-russ.com/2020/05/c...m-gates-fauci-coronavirus-vaccine-by-moderna/


    ----------------------------------------------------------

    Moderna would never release coronavirus vaccine data different from ‘reality,’ chairman says


    Moderna would never put out data on its potential vaccine for the coronavirus that was different from “reality,” the biotech firm’s chairman told CNBC on Wednesday.

    The comment came a day after health-care publication STAT News reported that some vaccine experts were skeptical of Moderna’s new vaccine data, saying it did not provide critical information to assess its effectiveness.

    https://www.cnbc.com/2020/05/20/mod...ata-different-from-reality-chairman-says.html
     
    BaghdadBob, May 20, 2020
    #233
  9. Bowerbird

    Bowerbird Well-Known Member

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    Ahhhhhh! Riiiiiight

    Because we should all get our information from obscure Russian blogs :roll::roll::roll:
     
    Bowerbird, May 21, 2020
    #234
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  10. BaghdadBob

    BaghdadBob Well-Known Member

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    overyerhed.png
     
    BaghdadBob, May 21, 2020
    #235
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  11. Woogs

    Woogs Well-Known Member

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    Scientists in China believe new drug can stop pandemic ‘without vaccine’
    Antibodies isolated from the blood of 60 recovered patients key to treatment that shortens recovery time, offers short-term immunity in mice
    By QIAN YE and MATTHEW KNIGHT19 May 2020, 4:31 pm 7
    [​IMG]
    This picture taken on May 14, 2020, shows researchers at Peking University's Beijing Advanced Innovation Center for Genomics conducting tests at their laboratory in Beijing. (Wang Zhao/AFP

    BEIJING, China (AFP) — A Chinese laboratory has been developing a drug it believes has the power to bring the coronavirus pandemic to a halt.

    The outbreak first emerged in China late last year before spreading across the world, prompting an international race to find treatments and vaccines.

    A drug being tested by scientists at China’s prestigious Peking University could not only shorten the recovery time for those infected, but even offer short-term immunity from the virus, researchers say.

    Sunney Xie, director of the university’s Beijing Advanced Innovation Center for Genomics, told AFP that the drug has
    successful at the animal testing stage.

    “When we injected neutralizing antibodies into infected mice, after five days the viral load was reduced by a factor of 2,500,” said Xie.

    “That means this potential drug has (a) therapeutic effect.”

    The drug uses neutralizing antibodies — produced by the human immune system to prevent the virus infecting cells — which Xie’s team isolated from the blood of 60 recovered patients.

    A study on the team’s research, published Sunday in the scientific journal Cell, suggests that using the antibodies provides a potential “cure” for the disease and shortens recovery time.

    https://www.timesofisrael.com/scien...e-new-drug-can-stop-pandemic-without-vaccine/
     
    Woogs, May 21, 2020
    #236
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  12. AmericanNationalist

    AmericanNationalist Well-Known Member

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    It would be great to get a potential fix to this problem, and even more poetic for it to come from Chinese scientists. To me, the world would owe it a debt of gratitude and in my view anyway I'd consider the matter settled, or mostly settled. Since I'm not the one affected but countless others around the world, so it varies but to me I'd lean towards some form of forgiveness.
     
    AmericanNationalist, May 21, 2020
    #237
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  13. Bowerbird

    Bowerbird Well-Known Member

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    And I am eternally grateful that I have a high level of immunity when it comes to whacked out conspiracy theories
     
    Bowerbird, May 21, 2020
    #238
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  14. LangleyMan

    LangleyMan Well-Known Member

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    Anti-vaxxer RFKJr. is not someone we should trust. As for side effects, we'll see if there's a problem and we don't need an update from Jr.
     
    LangleyMan, May 22, 2020
    #239
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  15. BaghdadBob

    BaghdadBob Well-Known Member

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    Remdesivir for the Treatment of Covid-19 — Preliminary Report

    https://www.nejm.org/doi/full/10.1056/NEJMoa2007764

    METHODS
    We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.

    RESULTS
    A total of 1063 patients underwent randomization.

    CONCLUSIONS
    Remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection.
     
    BaghdadBob, May 23, 2020
    #240
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  16. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, May 25, 2020
    #241
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  17. Woogs

    Woogs Well-Known Member

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    The World Health Organization has temporarily halted studying hydroxychloroquine as a potential Covid-19 treatment in its Solidarity Trial due to safety concerns, WHO Director-General Tedros Adhanom Ghebreyesus said during a briefing in Geneva on Monday.

    The decision was made after an observational study was published in the medical journal The Lancet on Friday, which described how seriously ill Covid-19 patients who were treated with hydroxychloroquine and chloroquine were more likely to die.

    Tedros said that an independent executive group is now reviewing the use of hydroxychloroquine in WHO's Solidarity Trial. The trial, which involves actively recruiting patients from more than 400 hospitals in 35 countries, is a global research effort to find safe and effective therapeutics for Covid-19.

    "The Executive Group of the Solidarity Trial, representing 10 of the participating countries, met on Saturday and has agreed to review a comprehensive analysis and critical appraisal of all evidence available globally," Tedros said on Monday.

    "The review will consider data collected so far in the Solidarity Trial and, in particular robust randomized available data, to adequately evaluate the potential benefits and harms from this drug," Tedros said. "The Executive Group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while the data is reviewed by the Data Safety Monitoring Board."
    Tedros added that the other arms of the trial are continuing.

    https://www.google.com/amp/s/amp.cn...coronavirus-pandemic-05-25-20-intl/index.html
     
    Woogs, May 25, 2020
    #242
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  18. Sallyally

    Sallyally Well-Known Member Donor

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    Sallyally, May 25, 2020
    #243
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  19. Bowerbird

    Bowerbird Well-Known Member

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    They are denying it of course and calling it “not a real study”.

    If it were not for Trump HCQ would not have had a second glance as it has already failed in vivo tests against SARS and MERS
     
    Bowerbird, May 25, 2020
    #244
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  20. BaghdadBob

    BaghdadBob Well-Known Member

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    Indian Govt expands Hydroxychloroquine as prophylactic for healthcare workers

    https://www.livemint.com/politics/p...ic-for-healthcare-workers-11590170414019.html

    "Another investigation from 3 central government hospitals in New Delhi indicates that amongst healthcare workers involved in COVID-19 care, those on HCQ prophylaxis were less likely to develop SARS-CoV-2 infection, compared to those who were not on it," stated the document.

    An observational prospective study of 334 healthcare workers at AIIMS, out of which 248 took HCQ prophylaxis (median 6 weeks of follow up) in New Delhi also showed that those taking HCQ prophylaxis had lower incidence of SARS-CoV-2 infection than those not taking it, it said.

    The National Institute of Virology, Pune reported in-vitro testing of HCQ for antiviral efficacy which showed a reduction of infectivity /log reduction in viral RNA copy of SARs-CoV2.
     
    BaghdadBob, May 26, 2020
    #245
  21. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, May 26, 2020
    #246
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  22. truth and justice

    truth and justice Well-Known Member

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    Something does not make sense here. They are advising that the drug is given to "All asymptomatic healthcare workers" If they are asymptomatic then they are already infected with the virus but not showing symptoms. Hence the drug is not being used as a prophylactic
     
    truth and justice, May 26, 2020
    #247
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  23. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, May 29, 2020
    #248
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  24. Sallyally

    Sallyally Well-Known Member Donor

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    Sallyally, May 29, 2020
    #249
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  25. ronv

    ronv Well-Known Member

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    Chloroquine shortage. :)
     
    ronv, May 29, 2020
    #250
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