The Push To Discredit HCQ

They don't read the post one article where it states that the drug was used in earlier outbreaks with good results, here is what they didn't read:

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Abstract

Background
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

Results
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

Conclusion
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.


LINK

 

Without placebos in place, you have no way of knowing if the patient would have gotten better anyway.

 

So you think all clinical trials are required to be blinded to get FDA approval? Yes or no will suffice.

 

If I had a solid opinion, I wouldn't be asking the questions. You seem hell bent on painting me into some sort of corner, though, so I'll ask my questions elsewhere.

Have a great day.

 

It was close to 200,000,000 by 1987.

 

I notice you ignored post 201 showing that the drug works against Corona Viruses. This was known 15 years ago........

Snicker..............

 

Another trying to paint me in a corner. I was asking about the concept of double-blind trials. It wasn't snark aimed against this particular drug. Sigh.

Good try, though.

 

You made a statement not an inquiry.

 

Fine. It was a point of discussion. I was respecting a non snark-filled counter.

How's this:

Okay, but without placebos in place, how would you know if the patient would have gotten better anyway?

 

It's been debated for decades regarding placebo effect and the ethics behind placebo arms.

Directly from NIH.

In randomized clinical trials, for conditions having no effective treatment, the control regimen with which the new treatment is compared, is warranted to establish the evidence. However, when an effective treatment already exists, it is unethical to create a placebo group that will receive no treatment. In other words, patients are deprived from an already existing effective therapy. The objective of testing such drugs to establish whether the new drug is better in efficacy or safety when compared to the existing drug/s placebo controlled trial considered unethical.

 

What's bizarro world is dems lying about what he actually said to discredit a drug. "shows promise" and
showing promise" now is "it's a cure". Lefties never ever change, they want things to be bad to win an election. It's a sickness that has become the left.

 

Thanks for actually bringing real world knowledge on clinical trials vs our resident lefties that actually believed if they stayed at a holiday inn they became experts on wtf ever pops up in their head.

 

Sorry to burst your bubble. Partisans on both sides cheer for the country to fail when team "other" is in charge. It's disgusting.

 

Thank you for a real answer. You weren't suggesting double blind trials are always bad, then? That's how I took it.

 

Your claim Trump said it was a cure. Back your claim up with a full context quote otherwise you fit the narrative. Don't move the goalposts. I never once cheered for our country to suffer in anyway regardless of who's running the show.

 

Exact words:

Trump tweeted “HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine,” and said that the drugs should be “put in use IMMEDIATELY. PEOPLE ARE DYING, MOVE FAST, and GOD BLESS EVERYONE!”

 

Nope, even stated a few times they are crucial in specific trials in my responses. They are just rarely used in today's clinical trials but when they are used, understanding the placebo effect is crucial.

 

You completely misunderstood the significance since it was already shown FIFTEEN years ago that it works on Corina viruses, which is similar to the Corona Virus of today.

Double blind trials are unnecessary this time around, and HUNDREDS of Doctors are on record in saying it works as long as you use it early, since its main strength is blocking the virus from entering the cell, the very same blocking capability known 15 tears earlier.

 

It's been explained to me, but thanks for the giant melt-down aimed at me. Not sure what I've done to offend you. Have a good day.

 

Having been prescribed for 60 years on label, it's safe to say the drug HAS been experimented with, and its efficacy has been demonstrated.

Many doctors have testified to the drug's efficacy, but those doctors are quickly censored and marginalized. That alone shows that somebody is trying to hide something.

Forget Trump. This is about the drug. 60 years of use show it to be effective.